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Purpose

Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future. This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.

Conditions

Eligibility

Eligible Ages
Over 21 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • > 21 years of age - In good physical & mental health - In stable physical & mental health - Have tried vaping - Former daily cigarette smokers who quit 1-20 year ago - Non-smokers who have not used tobacco or nicotine products

Exclusion Criteria

  • Has any respiratory disease (ex - asthma, COPD, etc...) - Has/had high blood pressure - Has/had liver disease - Has/had cancer - Has experience negative effects when vaped previously - Pregnant or nursing

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Intervention Model Description
All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons [PAHs].
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Other
D10-phenanthrene 		All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons [PAHs].
  • Other: D10-phenanthrene
    All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons [PAHs].

Recruiting Locations

University of Minnesota
Minneapolis, Minnesota 55455
Contact:
Aleksandra Alcheva
612-422-8902
alche003@umn.edu

More Details

Status
Recruiting
Sponsor
University of Minnesota

Study Contact

Aleksandra Alcheva
612-422-8902
alche003@umn.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.