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Purpose

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp[a]).

Condition

Eligibility

Eligible Ages
Between 50 Years and 105 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age ≥50 years - Lp(a)≥ 200 nmol/L during screening - Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis

Exclusion Criteria

  • Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia) - Prior or planned arterial revascularization - History of major bleeding disorder

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Olpasiran 		Participants will receive subcutaneous (SC) olpasiran.
  • Drug: Olpasiran
    Olpasiran will be administered via SC injection.
    Other names:
    • AMG 890
Placebo Comparator
Placebo 		Participants will receive SC placebo.
  • Drug: Placebo
    Placebo will be administered via SC injection.

Recruiting Locations

Advanced Cardiovascular LLC
Alexander City, Alabama 35010

University of Alabama Birmingham Saint Vincents Birmingham
Birmingham, Alabama 35205

Birmingham Clinical Research
Birmingham, Alabama 35209

Alliance For Multispecialty Research - Daphne
Daphne, Alabama 36526

Eastern Shore Research Institute
Fairhope, Alabama 36532

Heart Center Research LLC
Huntsville, Alabama 35801

CB Flock Research Corporation
Mobile, Alabama 36608

Phoenix Clinical
Phoenix, Arizona 85014

Elite Clinical Studies LLC
Phoenix, Arizona 85018

Hero Clinical Research
Phoenix, Arizona 85021

HonorHealth Research Institute
Scottsdale, Arizona 85258

Eclipse Clinical Research
Tucson, Arizona 85745

Lynn Institute of the Ozarks
Little Rock, Arkansas 72204

National Heart Institute
Beverly Hills, California 90211

310 Clinical Research
Inglewood, California 90301

University of California San Diego
La Jolla, California 92037

InvivoCure
Los Angeles, California 91405

Valley Clinical Trials
Northridge, California 91325

Clinical Trials Research - Sacramento
Roseville, California 95661

Alliance Clinical Research
San Diego, California 92120

Encompass Clinical Research
Spring Valley, California 91978

Manshadi Heart Institute
Stockton, California 95204

Blue Coast Cardiology
Vista, California 92083

Diablo Clinical Research
Walnut Creek, California 94598

Focus Clinical Research
West Hills, California 91307

Interventional Cardiology Medical Group
West Hills, California 91307

UCHealth Memorial Central
Colorado Springs, Colorado 80909

South Denver Cardiology Associates
Littleton, Colorado 80120

Gandelman Cardiology, PC
Greenwich, Connecticut 06830

Chase Medical Research LLC
Waterbury, Connecticut 06708

Excel Medical Clinical Trials
Boca Raton, Florida 33434

Clearwater Cardiovascular Consultants
Clearwater, Florida 33756

Proactive Clinical Research
Fort Lauderdale, Florida 33308

Indago Research and Health Center
Hialeah, Florida 33012

Elite Cardiac Research Center LLC
Hialeah, Florida 33013

Jacksonville Center for Clinical Research
Jacksonville, Florida 32216

East Coast Institute for Research, LLC
Lake City, Florida 32055

Columbus Clinical Services LLC
Miami, Florida 33125

Kendall South Medical Center
Miami, Florida 33175

Inpatient Research Clinic, LLC
Miami Lakes, Florida 33014

Panax Clinical Research
Miami Lakes, Florida 33014

Eminat, LLC
Miramar, Florida 33027

Suncoast Clinical Research Inc
New Port Richey, Florida 34652

Ocala Cardiovascular Research
Ocala, Florida 34471

Ocala Research Institute, Inc
Ocala, Florida 34474

Ormond Beach Clinical Research
Ormond Beach, Florida 32174

Baptist Health Care
Pensacola, Florida 32514

Denali Health Plant City
Plant City, Florida 33563

FWD Clinical Research
Tamarac, Florida 33321

Guardian Research Organization LLC
Winter Park, Florida 32792

Emory University Hospital
Atlanta, Georgia 30322

East Coast Institute for Research
Canton, Georgia 30114

Northeast Georgia Medical Center Wisteria Building
Cumming, Georgia 30041

Nsc Research
Johns Creek, Georgia 30024

Georgia Clinical Research
Lawrenceville, Georgia 30044

North Georgia Clinical Research
Woodstock, Georgia 30189

St Lukes Idaho Cardiology Associates
Meridian, Idaho 83642

Solaris Clinical Research
Meridian, Idaho 83646

Endeavor Health-Northwest Community Healthcare
Arlington Heights, Illinois 60005

Christie Clinic
Champaign, Illinois 61822

Advocate Lutheran General Hospital
Park Ridge, Illinois 60068

Alliance for Multispecialty Research, LLC - Park Ridge
Park Ridge, Illinois 66068

MediSphere Medical Research Center LLC
Evansville, Indiana 47714

Parkview Research Center
Fort Wayne, Indiana 46845

Franciscan Health Indianapolis
Indianapolis, Indiana 46237

Ascension Saint Vincent Heart Center
Indianapolis, Indiana 46290

Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana 46321

Reid Physician Associates
Richmond, Indiana 47374

MercyOne Iowa Heart Center
West Des Moines, Iowa 50266

Hutchinson Clinic PA
Hutchinson, Kansas 67502

University of Kansas Medical Center
Kansas City, Kansas 66160

Midwest Heart and Vascular Specialists
Overland Park, Kansas 66211

Graves Gilbert Clinic
Bowling Green, Kentucky 42101

The Research Group of Lexington LLC
Lexington, Kentucky 40503

Heart Clinic of Hammond
Covington, Louisiana 70433

Ima Clinical Research
Monroe, Louisiana 71201

Louisiana Heart Center
Slidell, Louisiana 70458

Monroe Research LLC
West Monroe, Louisiana 71291

Ascension Saint Agnes Heart Care
Baltimore, Maryland 21229

Johns Hopkins Hospital
Baltimore, Maryland 21287

Metropolitan Cardiovascular Consultants LLC
Beltsville, Maryland 20705

Suburban Hospital
Bethesda, Maryland 20814

Flourish Research
Bowie, Maryland 20715

Johns Hopkins University
Columbia, Maryland 21044

Centennial Medical Group
Columbia, Maryland 21045

Medstar Franklin Square Medical Center
Hyattsville, Maryland 20782

Capitol Cardiology Associates
Lanham, Maryland 20706

Brigham and Womens Hospital
Boston, Massachusetts 02115

Henry Ford Health System
Detroit, Michigan 48202

MyMichigan Medical Center Midland - Clinical Research Department
Midland, Michigan 48670

Advanced Cardiology Associates
Rochester Hills, Michigan 48307

Revival Research Institute
Southfield, Michigan 48034

Health East Cancer Care
Maplewood, Minnesota 55109

Mayo Clinic
Rochester, Minnesota 55905

Methodist Hospital
Saint Louis Park, Minnesota 55426

Jackson Heart Clinic
Jackson, Mississippi 39216

Cardiology Associates Research LLC
Tupelo, Mississippi 38801

Sisters of Saint Mary Health Heart and Vascular Care
Bridgeton, Missouri 63044

Washington University
St Louis, Missouri 63110

Bryan Heart
Lincoln, Nebraska 68506

Excel Clinical Research
Las Vegas, Nevada 89109

American Institute of Medical Research
Las Vegas, Nevada 89123

Las Vegas Clinical Trials
North Las Vegas, Nevada 89030

Renown Institute for Heart and Vascular Health
Reno, Nevada 89502

Advanced Heart and Vascular Institute of Hunterdon
Flemington, New Jersey 08822

Clinical Reseach Philadelphia Pennington
Hamilton, New Jersey 08690

Med Clinical Research Partners - Irvington
Irvington, New Jersey 07111

New Jersey Medcare / New Jersey Heart
Linden, New Jersey 07036

Saint Michaels Medical Center
Newark, New Jersey 07102

Circuit Clinical / Optum Medical Care of New Jersey
Secaucus, New Jersey 07094

The Heart House - Washington Township
Sewell, New Jersey 08080

CardioMetabolic Collaborative Clinic
Somerset, New Jersey 08873

Ima Clinical Research - Warren
Warren Township, New Jersey 07059

Albany Medical College
Albany, New York 12203

Basil Clinical
Inwood, New York 11096

Rasai Research
Jackson Heights, New York 11372

Crystal Run Healthcare
Monroe, New York 10950

Icahn School of Medicine at Mount Sinai
New York, New York 10029

Mount Sinai Queens
New York, New York 10029

Ima Clinical Research Manhattan
New York, New York 10036

Niagara Falls Memorial Medical Center
Niagara Falls, New York 14304

Circuit Clinical Orchard Park Family Practice
Orchard Park, New York 14127

Hudson Valley Cardiovascular Physicians PC
Poughkeepsie, New York 12601

Saratoga Clinical Research, LLC
Saratoga Springs, New York 12866

Moses H Cone Memorial Hospital
Greensboro, North Carolina 27401

Medication Management LLC
Greensboro, North Carolina 27405

Triad Clinical Trials, LLC
Greensboro, North Carolina 27410

Monroe Biomedical Research
Monroe, North Carolina 28112

Piedmont Healthcare
Statesville, North Carolina 28625

Accellacare Research of Wilmington
Wilmington, North Carolina 28401

Aultman Cardiology Clinical Trials
Canton, Ohio 44710

The Christ Hospital
Cincinnati, Ohio 45219

Velocity Clinical Research - Cincinnati
Cincinnati, Ohio 45219

Nexgen Research
Lima, Ohio 45801

K and R Research
Marion, Ohio 43302

Alliance for Multispecialty Research
Norman, Oklahoma 73069

University of Pennsylvania
Philadelphia, Pennsylvania 19104

Preferred Primary Care Physicians, Inc
Pittsburgh, Pennsylvania 15236

Pottstown Medical Specialists Inc
Pottstown, Pennsylvania 19464

Pharmacorp Clinical Trials Inc
Charleston, South Carolina 29412

Medical University of South Carolina
Charleston, South Carolina 29425

Prisma Health Carolina Cardiology - Greenville
Gantt, South Carolina 29605

Walker Family Care
Little River, South Carolina 29566

Accellacare Charleston
Mt. Pleasant, South Carolina 29464

Tribe Clinical Research - Spartanburg
Spartanburg, South Carolina 29301

Monument Health Clinical Research
Rapid City, South Dakota 57701

Erlanger Health, Inc.
Chattanooga, Tennessee 37403

Apex Research Foundation, LLC
Jackson, Tennessee 38301

Alliance for Multispecialty Research Knoxville
Knoxville, Tennessee 37909

Ascension Saint Thomas
Nashville, Tennessee 37205

Parkway Cardiology Associates
Oak Ridge, Tennessee 37830

Tennessee Center for Clinical Trials
Tullahoma, Tennessee 37388

PharmaTex Research, LLC
Amarillo, Texas 79106

Texas Diabetes and Endocrinology
Austin, Texas 78731

Ima Clinical Research
Austin, Texas 78745

Pioneer Medical Associates
Carrollton, Texas 75007

Baylor Scott and White Heart and Vascular Hospital-Dallas
Dallas, Texas 75226

Zenos Clinical Research
Dallas, Texas 75230

Cedar Health Research, LLC
Dallas, Texas 75251

Cedar Health Research, LLC
Euless, Texas 76040

East Texas Cardiology PA
Houston, Texas 77002

Baylor College of Medicine
Houston, Texas 77030

Cardiovascular Specialists of Willowbrook
Houston, Texas 77070

Vital Heart and Vein
Humble, Texas 77338

Tcr Institute Llc
Kingwood, Texas 77339

Epic Clinical Research
Lewisville, Texas 75057

Texas Tech University Health Sciences Center
Lubbock, Texas 79430

North Dallas Research Associates
McKinney, Texas 75069

Revival Research Institute
McKinney, Texas 75071

Texas Institute of Cardiology
McKinney, Texas 75071

Southern Endocrinology Associates PA
Mesquite, Texas 75149

Orion Medical
Pasadena, Texas 77505

Valley Institute of Research Plano
Plano, Texas 75024

Ima Clinical Research San Antonio
San Antonio, Texas 78229

St Davids Heart & Vascular PLLC dba Austin Heart
San Marcos, Texas 78666

Tyler Cardiovascular Consultants
Tyler, Texas 75701

Alpine Research Organization
Layton, Utah 84041

Inova Cardiology - Fairfax
Fairfax, Virginia 22031

Virginia Heart
Falls Church, Virginia 22042

Virginia Heart - Loudoun
Leesburg, Virginia 20176

Carient Heart and Vascular
Manassas, Virginia 20109

Bon Secours Cardiology
Midlothian, Virginia 23114

Tidewater Physicians Multispecialty Group Clinical Research
Newport News, Virginia 23606

Alliance for Multispecialty Research Norfolk
Norfolk, Virginia 23502

Centricity Research
Suffolk, Virginia 23435

Selma Medical Associates
Winchester, Virginia 22601

Winchester Medical Center
Winchester, Virginia 22601

Western Washington Medical Group
Everett, Washington 98208

Rainier Clinical Research Center
Renton, Washington 98057

More Details

Status
Recruiting
Sponsor
Amgen

Study Contact

Amgen Call Center
866-572-6436
medinfo@amgen.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.