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Purpose

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Have Lp(a) ≥175 nanomoles per liter (nmol/L) - Meet one of the following criteria: - Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening - Are at risk for a first ASCVD event, defined as one or more of the following: - Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event - A high coronary artery calcium (CAC) score - Reduced kidney function with diabetes - Combination(s) of high risk factors

Exclusion Criteria

  • Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization - Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study - Have uncontrolled high blood pressure - Have New York Heart Association (NYHA) class III or IV heart failure - Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study - Have severe kidney impairment - Have had cancer within 5 years prior to screening

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Muvalaplin 		Participants will receive muvalaplin orally.
  • Drug: Muvalaplin
    Administered orally
    Other names:
    • LY3473329
Placebo Comparator
Placebo 		Participants will receive placebo orally.
  • Drug: Placebo
    Administered orally

Recruiting Locations

Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona 85296
Contact:
480-691-2213

Axsendo Clinical Research - Peak Heart & Vascular - Phoenix
Phoenix, Arizona 85014
Contact:
602-730-9500

Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona 85375
Contact:
623-293-1360

Southwest Kidney Institute - Surprise
Surprise, Arizona 85374
Contact:
480-610-6100

Pima Heart
Tucson, Arizona 85741
Contact:
5203149254 ex 13563

National Heart Institute
Beverly Hills, California 90211
Contact:
310-289-9955

John Muir Medical Center - Concord Campus
Concord, California 94520
Contact:
925-674-2580

Neighborhood Healthcare Institute of Health
Escondido, California 92025
Contact:
760-737-6984

Ark Clinical Research - Fountain Valley
Fountain Valley, California 92708
Contact:
714-988-2021

Care Access - Huntington Beach
Huntington Beach, California 92648
Contact:
714-378-2440

The Cardiovascular Center
Redding, California 96001
Contact:
281-944-3610

UCLA South Bay Endocrinology
Torrance, California 90505

University of Colorado Anschutz Medical Campus
Aurora, Colorado 80045
Contact:
303-724-4651

Legacy Clinical Trials
Colorado Springs, Colorado 80909
Contact:
719-387-7572

Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut 06905
Contact:
203-353-1133

Chase Medical Research, LLC
Waterbury, Connecticut 06708
Contact:
203-419-4420

Excel Medical Clinical Trials
Boca Raton, Florida 33434
Contact:
305-631-6704

American Research Institute
Cutler Bay, Florida 33157

K2 Medical Research - Daytona Beach
Daytona Beach, Florida 32114

Arrow Clinical Trials
Daytona Beach, Florida 32117
Contact:
386-278-8000

Soffer Health Institute
Hollywood, Florida 33020

Jacksonville Center for Clinical Research
Jacksonville, Florida 32216
Contact:
904-730-0101

K2 MEDICAL Research THE VILLAGES
Lady Lake, Florida 32159
Contact:
352-500-5252

K2 Medical Research - Maitland
Maitland, Florida 32751
Contact:
407-810-2790

K2 Medical Research ORLANDO
Maitland, Florida 32751
Contact:
407-500-5252

Dade Florida Clinical Research Center
Miami, Florida 33173
Contact:
786-409-6842

Onhealth Research Center
Miami, Florida 33186

Advanced Research for Health Improvement, LLC
Naples, Florida 34102
Contact:
239-230-2021

Renstar Medical Research
Ocala, Florida 34471
Contact:
352-629-5800

Care Access - Tamarac
Tamarac, Florida 33321
Contact:
877-791-0656

Care Access - Tampa
Tampa, Florida 33625
Contact:
813-771-5980

Masters of Clinical Research
Augusta, Georgia 30909

Center for Advanced Research & Education
Gainesville, Georgia 30501
Contact:
770-534-5154

North Georgia Clinical Research
Woodstock, Georgia 30189
Contact:
678-494-5735

Elite Clinical Trials
Blackfoot, Idaho 83221
Contact:
208-643-0006

CARE Institute - High Desert
Meridian, Idaho 83642
Contact:
208-398-4306

Elite Clinical Trials
Rexburg, Idaho 83440
Contact:
208-356-8977

Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois 60640
Contact:
773-275-3500

AMR Clinical
Niles, Illinois 60714

IU Health Bloomington
Bloomington, Indiana 47408

Indiana University Health Methodist Hospital
Indianapolis, Indiana 46202

Tulane University School of Medicine
New Orleans, Louisiana 70112
Contact:
504-756-5621

MaineHealth Cardiology
Scarborough, Maine 04074

Ascension Saint Agnes Heart Care
Baltimore, Maryland 21229
Contact:
443-798-2670

Metropolitan Cardiovascular Consultants
Beltsville, Maryland 20750
Contact:
301-595-0356

Flourish Research - Bowie
Bowie, Maryland 20715
Contact:
410-824-1342

Johns Hopkins University
Columbia, Maryland 21044

Centennial Medical Group
Columbia, Maryland 21045
Contact:
410-730-3399

Anderson Medical Research
Ft. Washington, Maryland 20744
Contact:
301-542-6741

Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts 02115
Contact:
617-732-4245

Lucida Clinical Trials
New Bedford, Massachusetts 02740

Care Access - Quincy
Quincy, Massachusetts 02169
Contact:
877-791-0656

Revival Research Institute, LLC
Dearborn, Michigan 48126

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan 48098
Contact:
248-312-0025

Boeson Research MSO
Missoula, Montana 59804
Contact:
406-763-8833

Clinical Research of South Nevada
Las Vegas, Nevada 89121
Contact:
702-570-6107

Vector Clinical Trials
Las Vegas, Nevada 89128
Contact:
702-750-000

Vector Clinical Trials
Sparks, Nevada 89436
Contact:
775-877-9777

Clinical Research of Philadelphia
Pennington, New Jersey 08534
Contact:
215-676-6696

Cardio Metabolic Institute
Somerset, New Jersey 08873
Contact:
732-846-7000 x 108

IMA Clinical Research
Albuquerque, New Mexico 87109
Contact:
505-848-3773

Southwest Cardiovascular Center
Albuquerque, New Mexico 87112

Capital Cardiology Associates
Albany, New York 12211
Contact:
518-292-6216

NYC Research
New York, New York 10016
Contact:
516-574-9232

Weill Cornell Medical College
New York, New York 10021
Contact:
646-962-5558

Rochester Clinical Research, LLC
Rochester, New York 14609
Contact:
585-288-0890

Southgate Medical Group
West Seneca, New York 14224
Contact:
716-712-1004

Care Access - Fayetteville
Fayetteville, North Carolina 28314
Contact:
910-249-9855

Medication Management
Greensboro, North Carolina 27405
Contact:
336-763-6968

Kaiser Permanente Sunnyside Medical Center
Clackamas, Oregon 97015

Advanced Research Institute - Tigard
Tigard, Oregon 97223
Contact:
503-610-0033

Capital Area Research, LLC
Camp Hill, Pennsylvania 17011
Contact:
717-441-1725

Altoona Center For Clinical Research
Duncansville, Pennsylvania 16635
Contact:
814-693-0300

Clinical Research of Philadelphia
Philadelphia, Pennsylvania 19114
Contact:
215-676-6696

Keystone Clinical Studies
Plymouth Meeting, Pennsylvania 19462
Contact:
610-277-8073

M3 Wake Research - Charleston
Charleston, South Carolina 29414
Contact:
843-258-1852

Walker Family Care
Little River, South Carolina 29566
Contact:
843-280-8333

Circle Clinical Research
Sioux Falls, South Dakota 57104
Contact:
605-215-1159

WR-Clinsearch, LLC
Chattanooga, Tennessee 37397
Contact:
423-698-4584

The Jackson Clinic
Jackson, Tennessee 38305
Contact:
731-660-8396

PharmaTex Research
Amarillo, Texas 79106
Contact:
806-355-2581

St. David's Heart & Vascular PLLC dba Austin Heart
Austin, Texas 78756

Southwest Family Medicine Associates
Dallas, Texas 75235
Contact:
469-893-1242

Renal Disease Research Institute
Dallas, Texas 75246
Contact:
214-366-6125

IntraCare
Dallas, Texas 75254
Contact:
972-385-0000

UT Southwestern Medical Center
Dallas, Texas 75390

Texas Health Research & Education Institute - Fort Worth
Fort Worth, Texas 76104
Contact:
817-252-5000

Cedar Health Research - Fort Worth
Fort Worth, Texas 76132
Contact:
214-253-8170

Research Physicians Network, LLC
Houston, Texas 77089
Contact:
281-944-3610

GMG Clinical Research (DBA Radiance Clinical Research) - Lampasas
Lampasas, Texas 76550
Contact:
512-556-4130

Biopharma Informatic, LLC
McAllen, Texas 78503
Contact:
281-944-3610

Revival Research Institute, LLC
McKinney, Texas 75071

PRX Research
Mesquite, Texas 75149
Contact:
972-777-4428

ERA Health Research-Texas
Midland, Texas 79707
Contact:
432-528-7555

Sherman Clinical Research
Sherman, Texas 75090
Contact:
903-771-4093

Ogden Clinic - Canyon View
Ogden, Utah 84404
Contact:
385-271-0684

Advanced Research Institute
Ogden, Utah 84405
Contact:
801-409-2040

Virginia Heart
Falls Church, Virginia 22042
Contact:
703-766-5920

Carient Heart & Vascular - Manassas
Manassas, Virginia 20109
Contact:
703-335-8750

Manassas Clinical Research Center
Manassas, Virginia 20110
Contact:
703-330-1112

TPMG (Tidewater Physicians Multispecialty Group) Clinical Research
Newport News, Virginia 23606
Contact:
757-232-8836

York Clinical Research
Norfolk, Virginia 23504
Contact:
757-373-8478

Dominion Medical Associates, Inc.
Richmond, Virginia 23219
Contact:
804-249-2111

Carilion Clinic
Roanoke, Virginia 24014

ERA Health Research - CardioNow - Lynnwood
Lynnwood, Washington 98036
Contact:
425-869-6828

Eastside Research Associates
Redmond, Washington 98052
Contact:
425-869-6828

Rainier Clinical Research Center
Renton, Washington 98057
Contact:
425-251-1722

Universal Research Group
Tacoma, Washington 98405
Contact:
253-882-1070

Central Washington Health Services Association d/b/a Confluence Health
Wenatchee, Washington 98801
Contact:
509-436-4050

Clinical Investigation Specialists
Kenosha, Wisconsin 53144
Contact:
262-925-1280

Advanced Clinical Research, LLC
Bayamón, Puerto Rico 00959
Contact:
7872696590

Investigadores del Este
Humacao, Puerto Rico 00791
Contact:
787-409-8277

Research and Cardiovascular Corp.
Ponce, Puerto Rico 00717
Contact:
787-290-8585

More Details

Status
Recruiting
Sponsor
Eli Lilly and Company

Study Contact

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
1-317-615-4559
LillyTrials@Lilly.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.