A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
Purpose
Solid tumours are abnormal lumps of tissue that can occur in different parts of the body. The tumours involved in this study have specific genetic characteristics that can make them more aggressive and challenging to treat. The study will test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer agents can decrease tumor size, is safe, well-tolerated, and how the drug is processed in the body over time.
Conditions
- Neoplasms, Colorectal
- Neoplasms
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Has a histologically diagnosed advanced (unresectable, metastatic or recurrent) solid tumor - Has a known dMMR/MSI-H status as determined by a certified local laboratory at the time of Pre-screening or has an unknown Mismatch repair (MMR)/ Microsatellite Instability (MSI) status at the time of Pre-screening and MMR/MSI status will be determined by central reference laboratory - Provides an archival or fresh (preferred) formalin fixed, paraffin embedded (FFPE) sample - Intends to receive GSK5460025 as next treatment - Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 - Is expected to have a minimum of 3 months life expectancy - Has adequate organ function, as defined in the protocol Part 1 inclusion criteria: • Has histologically diagnosed advanced (unresectable, metastatic or recurrent) solid tumor and has exhausted all standard of care treatment options Part 2 inclusion criteria: - Has histologically diagnosed advanced (unresectable, metastatic or recurrent) Colorectal cancer (CRC) or Endometrial cancer (EC) - Has received at least 1 but no more than 3 lines of systemic anticancer therapy for their advanced (unresectable, metastatic or recurrent) disease including at least one line of Immune checkpoint inhibitors (ICI) therapy - Has measurable disease (i.e., at least 1 target lesion) during the Screening period per RECIST 1.1, as determined by the investigator
Exclusion Criteria
- Has not recovered (i.e., to Grade ≤1 or to baseline) from prior anticancer therapy-induced Adverse Events (AEs) - Has received prior treatment with a Werner (WRN) inhibitor or Nucleotide Excision Repair Targeting (NERT) agent. - Is unable to swallow and retain orally administered study treatment - Has untreated or progressed metastases in brain or CNS - Has a known additional malignancy that progressed or required active treatment within the last 2 years because reoccurrence of another malignancy would confound interpretation by RECIST 1.1 criteria. Exceptions include basal or squamous cell carcinomas of the skin or in situ carcinomas [e.g., breast, cervix, bladder] that have been resected with no evidence of metastatic disease. - Has any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drugs - Has cirrhosis or current unstable liver or biliary disease - Has known hypersensitivity to any of the study interventions or any of their excipients
Study Design
- Phase
- Phase 1/Phase 2
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Sequential Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Part 1: Dose escalation of GSK5460025 monotherapy |
Participants will receive GSK5460025 as monotherapy. |
|
|
Experimental Part 2: Dose expansion of GSK5460025 monotherapy |
Participants will receive GSK5460025 as monotherapy. |
|
Recruiting Locations
GSK Investigational Site
Aurora, Colorado 80045
Aurora, Colorado 80045
GSK Investigational Site
Detroit, Michigan 48201
Detroit, Michigan 48201
GSK Investigational Site
Canton, Ohio 44718
Canton, Ohio 44718
GSK Investigational Site
Nashville, Tennessee 37203
Nashville, Tennessee 37203
More Details
- Status
- Recruiting
- Sponsor
- GlaxoSmithKline