Print

Purpose

This Phase 3 study will be conducted in different countries around the world with up to about 528 participants. The purpose of this study is to evaluate how well Rina-S works against ovarian cancer in combination with available standard of care therapy that is already approved and used for ovarian cancer. Participants will receive either Rina-S monotherapy (by itself), Rina-S plus bevacizumab, bevacizumab (standard of care) by itself, or no treatment (only monitoring, also standard of care). No participants will be given placebo. Participants will participate in 1 of 2 arms. The treatment duration will be different for every participant. If a participant's cancer stays the same or gets better, and there are not any serious problems, participants can keep getting study treatment for as long as the study is open. Participants will be asked to attend 1 to 3 visits at the study clinic for each cycle (duration of cycle is 3 weeks). During visits, there will be various tests (such as blood draws) and procedures (such as recording of heart activity and imaging) to monitor whether the study treatment is safe and effective. The overall study duration (including screening, treatment, and follow-up) for each participant will be different for every participant.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Must have histologically or cytologically confirmed high-grade serous or endometrioid epithelial ovarian cancer (EOC), primary peritoneal cancer, or fallopian tube cancer. - Must have PSOC defined as progressive disease > 6 months (ie, 183 days) from the last dose of primary (first-line [1L]) platinum therapy. - Participants with known breast cancer (BRCA)-mutated (somatic or germline) or homologous recombination deficiency (HRD)-positive ovarian cancer who achieved complete response (CR)/no clinical evidence of disease (NED) or partial response (PR) following 1L platinum-based chemotherapy regimen must have previously received PARPi maintenance therapy as part of their 1 L treatment. - Must have completed platinum-based chemotherapy in the 2L treatment for recurrent PSOC. - Must have received platinum-based chemotherapy in the 1L treatment and received platinum-based chemotherapy in the 2L treatment. - Must be randomized no later than 8 weeks from the last dose of the 2L platinum-based therapy. - Participants must have achieved a CR/NED, PR, or SD, as assessed by the investigator, following completion of 2L platinum-based chemotherapy.

Exclusion Criteria

  • Participants with clear cell, mucinous, or sarcomatous histology, mixed tumors containing any of the above histologies, or low-grade/borderline ovarian tumors - More than 2 prior lines of systemic therapy. - Progression while on or following 2L platinum-based regimen prior to randomization. - Participants who receive an intervening systemic anticancer treatment (excluding bevacizumab) after the last dose of 2L platinum-based chemotherapy and prior to randomization. Note: Other protocol-defined Inclusion and Exclusion criteria may apply.

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Rina-S + SOC 		Participants will receive Rina-S and SOC consisting of either bevacizumab maintenance or no maintenance treatment (observation).
  • Drug: Rina-S
    Intravenous (IV) infusion
    Other names:
    • Rinatabart sesutecan
    • GEN1184
    • PRO1184
  • Drug: Bevacizumab
    IV infusion
Active Comparator
SOC 		Participants will receive SOC consisting of either bevacizumab maintenance or no maintenance treatment (observation).
  • Drug: Rina-S
    Intravenous (IV) infusion
    Other names:
    • Rinatabart sesutecan
    • GEN1184
    • PRO1184
  • Drug: Bevacizumab
    IV infusion

Recruiting Locations

Mt. Sinai Comprehensive Cancer Center
Miami 4164138, Florida 4155751 33140

More Details

Status
Recruiting
Sponsor
Genmab

Study Contact

Genmab Trial Information
+4570202728
clinicaltrials@genmab.com

Detailed Description

This is a randomized, open-label, Phase 3 study of Rina-S + standard of care (SOC) versus SOC as maintenance treatment after second-line (2L) platinum-based doublet chemotherapy in participants with recurrent PSOC.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.