Purpose

This study will look at how eating peanuts every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding peanuts to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating peanuts improves overall diet quality and health markers like tiredness and certain levels in blood.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 80 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been using semaglutide or tirzepatide for a clinical indication or at least 6 months

Exclusion Criteria

  • No use or contraindication to use of a GLP-1 RA - Known allergy to nuts - Pregnant or breastfeeding - Incarcerated

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Supportive Care
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Peanut Group
Participants in this group will eat 2 ounces, or 53 grams of dry-roasted, lightly salted (low sodium) each day along with their regular diet.
  • Dietary Supplement: Peanuts
    Participants will eat 2 ounces, or about 53 grams, of dry-roasted, lightly salted peanuts each day along with their regular diet
  • Procedure: Dual-energy X-ray absorptiometry (DEXA) scans
    DEXA scans will be used to measure body fat
Active Comparator
No Peanut Group
Participants in this group will continue eating regular diet without peanuts.
  • Procedure: Dual-energy X-ray absorptiometry (DEXA) scans
    DEXA scans will be used to measure body fat

Recruiting Locations

University Hospitals Cleveland Medical Center
Clevland, Ohio 44106
Contact:
Ian Neeland, MD
216-844-5965
Ian.Neeland@UHhospitals.org

More Details

Status
Recruiting
Sponsor
Ian J. Neeland, MD

Study Contact

Ian Neeland, MD
216-844-5965
Ian.Neeland@UHhospitals.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.