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Purpose

This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age ≥18 years - Diagnosis of OAG (including exfoliative or pigmentary) or OHT - Gonioscopically open angle (visible scleral spur 360°) - Ability to consent and comply with follow-up

Exclusion Criteria

  • Angle-closure or secondary glaucomas - IOP >35 mmHg despite therapy - Corneal pathology interfering with laser or IOP measurement - Recent ocular surgery (<6 months) - Contraindications to study medications or procedures - Cognitive impairment preventing consent

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Direct Selective Laser Trabeculoplasty 		This arm is going to receive the Direct SLT treatment
  • Device: Direct Selective laser Trabeculoplasty
    The Direct Selective Laser Trabeculoplasty is a non-contact laser designed to manage IOP in patients with glaucoma. The traditional SLT required a gonioscopy lens to be placed over the patient's eyes to direct the laser towards the trabecular meshwork.
Active Comparator
Traditional Selective Laser Trabeculoplasty 		This arm is going to receive the Traditional SLT treatment which will act as a control for the experimental arm. Note that both lasers are Standard of Care (SOC) and FDA approved
  • Device: Direct Selective laser Trabeculoplasty
    The Direct Selective Laser Trabeculoplasty is a non-contact laser designed to manage IOP in patients with glaucoma. The traditional SLT required a gonioscopy lens to be placed over the patient's eyes to direct the laser towards the trabecular meshwork.

Recruiting Locations

MUSC
Charleston, South Carolina 29407
Contact:
Jella An, MD, MBA
843-792-1443
anjel@musc.edu

More Details

Status
Recruiting
Sponsor
Medical University of South Carolina

Study Contact

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.