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Purpose

The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Condition

Eligibility

Eligible Ages
Over 40 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center - Planned clinical electrode trajectory that contacts caudate - Age greater than or equal to 40 - Diagnosis of Parkinson's disease or other movement disorder - Able to participate in intraoperative testing - English speaking

Exclusion Criteria

  • Age less than 40 - Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Neural recordings and stimulation
  • Other: Neurophysiology recordings
    Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
  • Other: Neural stimulation
    Neural stimulation will be delivered during a gambling task and its impact on task performance quantified

Recruiting Locations

Vanderbilt University Medical Center
Nashville 4644585, Tennessee 4662168 37212
Contact:
Isabel Long, BS
615-421-3046
isabel.long@vumc.org

More Details

Status
Recruiting
Sponsor
Vanderbilt University Medical Center

Study Contact

Isabel Long, BS
615-421-3046
isabel.long@vumc.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.