Print

Purpose

This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit. - Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF.

Exclusion Criteria

  • Participant is not eligible for study treatment per the parent study eligibility criteria. - Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study. - Participants not receiving clinical benefit from parent study drug as assessed by the investigator. Other protocol defined inclusion/exclusion criteria applies.

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
N/A
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm A1
  • Drug: Adagrasib
    Specified dose on specified days
    Other names:
    • BMS-986503
Experimental
Arm A2
  • Drug: Adagrasib
    Specified dose on specified days
    Other names:
    • BMS-986503
Experimental
Arm B1
  • Drug: Adagrasib
    Specified dose on specified days
    Other names:
    • BMS-986503
  • Drug: Pembrolizumab
    Specified dose on specified days
Experimental
Arm B2
  • Drug: Adagrasib
    Specified dose on specified days
    Other names:
    • BMS-986503
  • Drug: Pembrolizumab
    Specified dose on specified days
Experimental
Arm B3
  • Drug: Adagrasib
    Specified dose on specified days
    Other names:
    • BMS-986503
  • Drug: Cetuximab
    Specified dose on specified days
Experimental
Arm B4
  • Drug: Adagrasib
    Specified dose on specified days
    Other names:
    • BMS-986503
  • Drug: Pembrolizumab
    Specified dose on specified days
  • Drug: Pemetrexed
    Specified dose on specified days
Experimental
Arm C1
  • Drug: Pembrolizumab
    Specified dose on specified days
Experimental
Arm C2
  • Drug: Docetaxel
    Specified dose on specified days
Experimental
Arm C3
  • Drug: Irinotecan
    Specified dose on specified days
  • Drug: Leucovorin
    Specified dose on specified days
    Other names:
    • Folinic acid
  • Drug: Fluorouracil
    Specified dose on specified days
Experimental
Arm C4
  • Drug: Leucovorin
    Specified dose on specified days
    Other names:
    • Folinic acid
  • Drug: Oxaliplatin
    Specified dose on specified days
  • Drug: Fluorouracil
    Specified dose on specified days

Recruiting Locations

Southern California Permanente Medical Group
Bellflower, California 90706
Contact:
Gary Buchschacher, Site 0016
000-000-0000

Florida Cancer Specialists - North
St. Petersburg, Florida 33701
Contact:
Maen Hussein, Site 0001
727-216-1143

Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota 55905
Contact:
Konstantinos Leventakos, Site 0017
507-284-2511

Oncology Associates Of Oregon, Pc
Eugene, Oregon 97401
Contact:
Jeff Porter Sharman, Site 0004
888-542-2525

The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee 38138
Contact:
Ramakrishna Battini, Site 0023
901-683-0055

Texas Oncology-Bedford
Bedford, Texas 76022
Contact:
Kartik Konduri, Site 0117
214-370-1000

Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas 75246
Contact:
Kartik Konduri, Site 0118
214-370-1000

Texas Oncology - DFW
Grapevine, Texas 76051
Contact:
Kartik Konduri, Site 0002
214-370-1000

More Details

Status
Recruiting
Sponsor
Mirati Therapeutics Inc.

Study Contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
855-907-3286
Clinical.Trials@bms.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.