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Purpose

The purpose of this modular, first trial in human study is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of ascending dose levels (DLs) of AZD4956 monotherapy and in combination with other anti-cancer agents in participants with advanced/metastatic solid tumours with homologous recombination repair (HRR) deficiencies.

Condition

Eligibility

Eligible Ages
Between 18 Years and 130 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Documented locally advanced or metastatic solid tumour malignancy. - Eastern cooperative oncology group (ECOG) performance status of 0 or 1 with no deterioration over the previous 2 weeks prior to screening and first day of dosing. - Minimum life expectancy ≥ 12 weeks. - Adequate organ and marrow function. - Female participants must not breastfeed and must not donate or retrieve ova for their own use from screening to approximately 6 months after the last dose of study intervention. Module 1 Inclusion Criteria: - Demonstrated evidence of disease progression. - Participants must have advanced or metastatic solid tumours. - Participants may have received up to one prior line of therapy with a poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi)-based regimen (either as a treatment or as maintenance). Module 2 Inclusion Criteria: Part A (AZD4956 in Combination with Saruparib Dose Escalation) and Part A-PD (PD Backfill Cohorts): - Participants must have one of the following conditions- 1. Histologically or cytologically confirmed carcinoma of the breast with recurrent locally advanced or metastatic disease and evidence of a predicted loss of function germline or somatic mutation. 2. Histologically or cytologically confirmed advanced ovarian, fallopian tube, or primary peritoneal cancer. 3. Histologically or cytologically confirmed adenocarcinoma of the prostate and advanced/metastatic castrate resistant prostate cancer (CRPC). 4. Histologically or cytologically confirmed advanced/metastatic pancreatic cancer. - Participants must have evaluable disease. - Participants in PD backfill cohorts must not have received prior therapy with a PARPi-based regimen (either as a treatment or as maintenance). Part A (PD Backfill Cohorts) - Participants Undergoing Paired Biopsies: - Participants must have a tumour suitable for biopsy. Part A-Non-PD (Non-PD Backfill Cohorts) and Part B (Dose Expansion Cohorts): - Participants must have histologically or cytologically confirmed adenocarcinoma of the prostate and advanced/metastatic CRPC. - Participants must have documented metastatic disease by clear evidence of ≥ 1 bone lesion (defined as one lesion with positive uptake on bone scan) and/or ≥ 1 soft tissue lesion (measurable or non-measurable). - Participants must have received the prior approved systemic therapies for metastatic prostate cancer. - Participants must not have received prior therapy with a PARPi-based regimen (either as a treatment or as maintenance). Core

Exclusion Criteria

  • Any significant laboratory finding or any severe and uncontrolled medical condition. - Participants with any known predisposition to bleeding. - Spinal cord compression or symptomatic and unstable brain metastases or leptomeningeal disease. - Allogenic organ transplantation. - Known to have active infection, including hepatitis B virus (HBV) or hepatitis C virus (HCV). - Known history of infection with human immunodeficiency virus (HIV). - Active gastrointestinal disease or other condition that will interfere significantly with the swallowing, absorption, distribution, metabolism or excretion of oral therapy. - Participants with history of myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML) or with features suggestive of MDS/AML. - Participants with a known hypersensitivity to the investigational product(s) or any of the excipients of the product(s). - Previous dosing with AZD4956.

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Sequential Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Module 1 Part A: AZD4956 monotherapy (Dose escalation) 		Participants will receive AZD4956 as monotherapy at ascending dose levels.
  • Drug: AZD4956
    AZD4956 will be administered orally.
Experimental
Module 2 Part A: AZD4956 + saruparib (Dose escalation) 		Participants will receive AZD4956 at ascending dose levels in combination with saruparib.
  • Drug: AZD4956
    AZD4956 will be administered orally.
  • Drug: Saruparib
    Saruparib will be administered orally.
Experimental
Module 2 Part A Optional PD backfill cohort: AZD4956 + saruparib 		Participants will receive AZD4956 in combination with saruparib.
  • Drug: AZD4956
    AZD4956 will be administered orally.
  • Drug: Saruparib
    Saruparib will be administered orally.
Experimental
Module 2 Part A Optional PD backfill cohort: Saruparib monotherapy 		Participants will receive saruparib monotherapy.
  • Drug: Saruparib
    Saruparib will be administered orally.
Experimental
Module 2 Part A Optional non-PD backfill cohort: AZD4956 + saruparib 		Participants with metastatic castrate resistant prostate cancer (mCRPC) will receive AZD4956 in combination with saruparib.
  • Drug: AZD4956
    AZD4956 will be administered orally.
  • Drug: Saruparib
    Saruparib will be administered orally.
Experimental
Module 2 Part B: AZD4956 + saruparib (Dose expansion) 		Participants will receive AZD4956 in combination with saruparib.
  • Drug: AZD4956
    AZD4956 will be administered orally.
  • Drug: Saruparib
    Saruparib will be administered orally.

Recruiting Locations

Research Site
Fairfax, Virginia 22031

More Details

Status
Recruiting
Sponsor
AstraZeneca

Study Contact

AstraZeneca Clinical Study Information Center
1-877-240-9479
information.center@astrazeneca.com

Detailed Description

The study consists of individual modules each evaluating the safety and tolerability of AZD4956 dosed as monotherapy, or with a specific combination partner. There are following 2 modules - 1. Module 1: AZD4956 monotherapy 2. Module 2: AZD4956 in combination with saruparib Each module may further contain 2 parts- - Part A (dose escalation/dose finding): To determine the safety, tolerability, PK, PD, and preliminary efficacy of AZD4956 as monotherapy or in combination. - Part B (dose expansion): To further evaluate the safety and preliminary efficacy of AZD4956 in combination with other anti-cancer agents.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.