Neural Mechanisms of the Social Brain
Purpose
This study aims to understand the neural mechanisms that underlie synchronization of two brains during social interactions.
Condition
- Live Face Processing in Typically Developed Participants
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Self reported typically developed adults.
Exclusion Criteria
- No prior history of seizure activity. Self reported absence of recreational drugs at time of study.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Sham Comparator Sham Comparator |
TMS to a non-targeted region. |
|
|
Experimental Experimental Comparator |
TMS to targeted regions |
|
Recruiting Locations
New Haven, Connecticut 06511
More Details
- Status
- Recruiting
- Sponsor
- Yale University
Detailed Description
After being informed about the study and potential risks, all participants giving written informed consent will undergo a structural MRI image for anatomical localization of the targeted stimulation site. Participants will be randomly assigned to one of two TMS target locations, and will be identified for the TMS experiments. Two to three days prior to the TMS experiment, participants will undergo a before TMS/fNIRS experiment. On the day of the TMS experiment participants will undergo a functional dyadic neuroimaging session after TMS stimulation. For the neuromodulation experiments, tDCS, selected sites for stimulation will be identified on the T1 anatomical scans for each participant who will be randomly assigned to one of three groups. In each case the face-gaze fNIRS experiment will be run. Aim 2: Two targeted sites will be confirmed as neural hubs by modification of fiducial neural regions based on the findings of cTBS disruptions. Rationale: These locations and functional specializations are necessary for the proposed neuromodulation tests in the upcoming clinical trial phase. Part 1: Stimulate to disrupt the site associated with eye-to-eye contact hypothesized to be right superior parietal lobule. Part 2: Stimulate to disrupt the site associated with live face gaze hypothesized to be right supramarginal gyrus. The focus of this registration is Aim 2.