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Purpose

The purpose of this study is to see how well Photon Counting CT (PCCT) and ultrasound test results can find fat and scarring in the liver. They will be compared to MRI test results as the reference standard. Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study. They will also get an MRI, either on the same day or a different day, whichever is preferred. Participants will get an ultrasound on the same day as the MRI. If they have not had a hematocrit blood test in the past 24 hours, they will also receive one on the day of the CT scan.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age of 18 years or older - Has clinically indicated CT schedule including the liver (with contrast or with and without contrast) - Patient eligible for MR imaging - History of chronic diffuse liver disease, steatotic liver disease, and/ or liver fibrosis - Capable of consent

Exclusion Criteria

  • Contraindications to any of the required imaging examinations - BMI > 45 (based on MRI scanner capacity)

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Single Group Assignment
Primary Purpose
Diagnostic
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Photon Counting CT (PCCT) 		Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study.
  • Diagnostic Test: Photon-counting CT (PCCT)
    Photon-counting computed tomography (PCCT) is a next-generation imaging technology using advanced detectors that directly count individual X-ray photons and measure their energy, rather than integrating total energy like traditional CT.
Active Comparator
MRI 		Participants will get an MRI, either on the same day as the PCCT scan or a different day, whichever is preferred.
  • Diagnostic Test: Magnetic Resonance Imaging (MRI)
    MRI is a noninvasive, radiation-free medical imaging technique that uses powerful magnets and radio waves to generate detailed, high-resolution 3D images of soft tissues, organs, and bones.
Active Comparator
Ultrasound 		Participants will get an ultrasound on the same day as the MRI.
  • Diagnostic Test: Ultrasound
    Ultrasound is a safe, radiation-free imaging technique using high-frequency sound waves to visualize soft tissues, organs, and blood flow in real-time.

Recruiting Locations

Duke University Medical Center
Durham, North Carolina 27710
Contact:
Elisabeth Luck CCRC
919-684-7752
mary.luck@duke.edu

More Details

Status
Recruiting
Sponsor
Duke University

Study Contact

Mustafa Bashir, MD
919-684-7366
mustafa.bashir@duke.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.