Purpose

Researchers are looking for new ways to treat 2 types of non-Hodgkin lymphoma (NHL) called follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). FL is a slow-growing type of NHL. DLBCL is a fast-growing type of NHL. NHL is a cancer in the lymphatic system that causes swollen lymph nodes. The lymphatic system is part of the immune system. In this study, researchers want to learn if MK-1045 can treat FL and DLBCL. MK-1045 is a study treatment that is an immunotherapy, which helps the immune system fight cancer. The goals of this study are to learn how safe MK-1045 is and if people tolerate it. Researchers also want to see if FL and DLBCL respond (the cancer gets smaller or goes away) to treatment.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

The main inclusion criteria include but are not limited to the following: - Has disease that has relapsed (disease progression after remission) or is refractory (failure to achieve complete or partial response) to at least 2 prior systemic lines of therapy. - Has a histologically confirmed diagnosis of follicular lymphoma (FL) or diffuse large B-cell lymphoma (DLBCL). - DLBCL participants only: has progressed after or is ineligible for transplant and chimeric antigen receptor T (cell) (CAR-T) therapy. - Has provided tumor tissue sample (archival or newly obtained, if performed per standard of care). - Has documented retained expression of cluster of differentiation 19 (CD19) in tumor tissue obtained by biopsy after disease progression on CD19-targeting therapy, if experienced disease progression after prior CD19-targeting therapy. - Has well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy if has a history of HIV infection. - Has undetectable hepatitis B virus (HBV) viral load and received and will continue to receive HBV antiviral therapy if hepatitis B surface antigen (HBsAg)-positive. - Has undetectable hepatitis C virus (HCV) viral load and received HCV antiviral therapy if has a history of HCV infection. - Has radiographically measurable disease per Lugano Response Criteria.

Exclusion Criteria

The main exclusion criteria include but are not limited to the following: - Has received a solid organ transplant. - Had or has clinically relevant central nervous system (CNS) diseases. - Has a history of serious cardiovascular or cerebrovascular diseases. - Had prior allogenic stem cell transplantation with acute graft-versus-host-disease (GVHD); has ongoing evidence of chronic GVHD manifesting as skin involvement, diarrhea, or increased serum bilirubin; or requires systemic immunosuppression for GVHD. - Is HIV-infected with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease. - Has received a live or live-attenuated vaccine within 30 days of randomization. - Has received prior CAR-T therapy within 3 months before the first dose of the study intervention. - Has a known additional malignancy that is progressing or required active treatment within the past 2 years. - Has known active CNS lymphoma or involvement. - Has active autoimmune disease that required systemic treatment in the past 2 years. - Has active infection requiring systemic therapy. - Has a history of severe bleeding disorders. - Has not recovered from major surgery or has ongoing surgical complications. - Has diagnosis of primary mediastinal B-cell lymphoma.

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm 1: Follicular Lymphoma (FL) MK-1045 Monotherapy Dose Optimization
Participants will receive Dosage A of MK-1045 by Intravenous (IV) infusion for up to approximately 1 year of treatment or until discontinuation.
  • Biological: MK-1045
    Intravenous (IV) Infusion or Subcutaneous (SC) injection
    Other names:
    • CN-201
Experimental
Arm 2: FL MK-1045 Longer Dosing Interval
Participants will receive Dosage B of MK-1045 by Intravenous (IV) infusion for up to approximately 1 year of treatment or until discontinuation.
  • Biological: MK-1045
    Intravenous (IV) Infusion or Subcutaneous (SC) injection
    Other names:
    • CN-201
Experimental
Arm 3: FL MK-1045 Subcutaneous Administration
Participants will receive Dosage C of MK-1045 by subcutaneous (SC) injection for up to approximately 1 year of treatment or until discontinuation.
  • Biological: MK-1045
    Intravenous (IV) Infusion or Subcutaneous (SC) injection
    Other names:
    • CN-201
Experimental
Arm 4: Diffuse Large B-cell Lymphoma (DLBCL) MK-1045 Monotherapy Dose Optimization
Participants will receive Dosage D of MK-1045 by Intravenous (IV) infusion for up to approximately 1 year of treatment or until discontinuation.
  • Biological: MK-1045
    Intravenous (IV) Infusion or Subcutaneous (SC) injection
    Other names:
    • CN-201

Recruiting Locations

SCRI Oncology Partners ( Site 0100)
Nashville, Tennessee 37203
Contact:
Study Coordinator
844-482-4812

More Details

Status
Recruiting
Sponsor
Merck Sharp & Dohme LLC

Study Contact

Toll Free Number
1-888-577-8839
Trialsites@msd.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.