GLOW Study: Effects of Triple Protein in Women
Purpose
This single-site, randomized, blinded, placebo-controlled study will evaluate whether 4 weeks of daily Triple Support Protein powder improves glycemic control and overall well-being in healthy women aged 30-60 years. Participants will undergo baseline testing (DXA, fasting blood, standardized meal test with 2-hour glucose and insulin sampling), complete one acute supervised dose, and then consume a daily supplement for 4 weeks. During the final 14 days, participants will wear a continuous glucose monitor. Outcomes include postprandial glucose AUC, insulin sensitivity, and body composition.
Condition
- Healthy Women
Eligibility
- Eligible Ages
- Between 30 Years and 60 Years
- Eligible Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Females aged 30-60 years. - BMI 18.5-40 kg/m^2. - Recreationally active (≥30 min/wk moderate intensity exercise). - Healthy and free from disease per health history questionnaire. - Willing to abstain from caffeine, tobacco, and alcohol for 24 hours before testing days.
Exclusion Criteria
- Currently supplementing whey protein. - Pregnant or nursing. - Lactose intolerant. - Currently using creatine monohydrate. - Severe hearing or speech impairment or inability to speak English
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Intervention Model Description
- Randomized, double-blind, placebo controlled parallel design
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Investigator)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Triple Protein Support |
Daily one serving of plant-based protein + creatine + fiber mixed with 8-12 fl oz water for 4 weeks |
|
|
Placebo Comparator Placebo |
Daily one serving of a non-caloric, texture- and weight-matched placebo for 4 weeks |
|
Recruiting Locations
Chapel Hill, North Carolina 27713
More Details
- Status
- Recruiting
- Sponsor
- University of North Carolina, Chapel Hill
Detailed Description
Midlife women experience hormonal changes that can impair metabolic health, sleep, and cognition. Triple plant-based protein powder includes creatine and fiber aimed at glycemic control, muscle support, and satiety. Design: 40 participants randomized (1:1) to Triple Protein Support vs. matched placebo for 4 weeks, with acute and chronic phases, weekly check-ins. Assessments: Baseline and end-of-study DXA and bloods; standardized meal tests with 2-hour glucose/insulin sampling; Analysis: Mixed-model ANOVA for primary and secondary endpoints with α=0.05.