A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants
Purpose
The purpose of this study is to learn about the safety of a new pneumococcal vaccine and how the new pneumococcal vaccine helps to fight against germs that can cause pneumonia (lung infections), meningitis (brain infections), and otitis media (ear infections) in infants when compared to the pneumococcal vaccine that is currently in use, 20vPnC (Prevnar 20®). This study will test if the new pneumococcal vaccine is as safe as the one that is currently in use. This new vaccine can possibly provide additional protection against germs that cause pneumococcal disease that are not included in the vaccines that are currently given to infants. Pneumococcal disease includes a variety of infections caused by a specific germ, Streptococcus pneumoniae. There are two groups in this study. All participants will be assigned to one of the two groups. This study is seeking participants who are: - infants who are about 2 months of age About 2400 infants will be assigned by chance to one of the two groups to receive either PG4 (new vaccine) or 20vPnC (currently in use) into the left thigh muscle at 2, 4, 6, and 12 to 15 months of age. Infants will take part in this study for about 16 to 19 months (about 1 and a half years). During this time, infants will have 6 study clinic visits and 1 phone call. At these study clinic visits, parent(s)/legal guardian(s) will be asked if the infant experienced any side effects. A side effect is an unintentional or unexpected reaction to a vaccine.
Condition
- Pneumococcal Disease
Eligibility
- Eligible Ages
- Between 42 Days and 98 Days
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Infants who are about 2 months of age - Healthy infants determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study.
Exclusion Criteria
- History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis). - Major known congenital malformation or serious chronic disorder. - Other acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study. - Previous vaccination with any licensed or investigational pneumococcal vaccine, or planned receipt through study participation.
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Intervention Model Description
- Parallel assignment
- Primary Purpose
- Prevention
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental PG4 (intramuscular) |
Multivalent Pneumococcal Vaccine |
|
|
Active Comparator 20-valent pneumococcal conjugate vaccine (20vPnC) (intramuscular) |
20-valent pneumococcal conjugate vaccine (20vPnC) |
|
Recruiting Locations
Estero, Florida 33928
Fort Lauderdale, Florida 33304
Fort Myers, Florida 33908
Union City, Georgia 30291
Idaho Falls, Idaho 83404
Bardstown, Kentucky 40004
Shreveport, Louisiana 71101
Shreveport, Louisiana 71101
Shreveport, Louisiana 71103
Shreveport, Louisiana 71103
Hawthorne, New York 10532
Valhalla, New York 10595
South Euclid, Ohio 44121
Oklahoma City, Oklahoma 73103
Gresham, Oregon 97030
Simpsonville, South Carolina 29680
Gordonsville, Virginia 22942
More Details
- Status
- Recruiting
- Sponsor
- Pfizer