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Purpose

Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.

Condition

Eligibility

Eligible Ages
Between 18 Years and 99 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Body Mass Index (BMI) ≥ 25 at screening. - Weight loss of ≥ 10% on weekly GLP-1 RA. - Stable body weight. - Stable dose of GLP-1RA. - Stable gastrointestinal (GI) tolerability. - Contraception for females. - Willingness to follow trial procedures for the duration of the trial.

Exclusion Criteria

  • Obesity induced by other endocrine disorders (ex: Cushing's syndrome). - Previous or planned surgical, endoscopic or device-based treatment for obesity. - History of malignancy. - Type 1/Type 2 diabetes mellitus (DM). - Family or personal history of medullary thyroid cancer. - Previous participation in a Maridebart Cafraglutide trial.

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
MariTide Arm 1 		Participants will receive maridebart cafraglutide dosing schedule 1 during the treatment period.
  • Drug: Maridebart Cafraglutide
    Maridebart cafraglutide will be administered via subcutaneous (SC) injection.
    Other names:
    • AMG 133
Experimental
MariTide Arm 2 		Participants will receive maridebart cafraglutide dosing schedule 2 during the treatment period.
  • Drug: Maridebart Cafraglutide
    Maridebart cafraglutide will be administered via subcutaneous (SC) injection.
    Other names:
    • AMG 133

Recruiting Locations

Cahaba Research, Inc.
Pelham, Alabama 35124

Arizona Clinical Trials
Chandler, Arizona 85224

Epic Medical Research - Sun City
Sun City, Arizona 85351

Desert Oasis Healthcare Medical Group
Palm Springs, California 92262

Inland Empire Liver Foundation
Rialto, California 92377

Peninsula Research Associates
Rolling Hills Estates, California 90274

Apex Clinical Research
San Diego, California 92120

Southern California Clinical Research
Santa Ana, California 92701

Aga Clinical Trials
Hialeah, Florida 33012

South Florida Clinical Research
Margate, Florida 33063

New Horizon Research Center
Miami, Florida 33165

Research Institute of South Florida
Miami, Florida 33173

Clinical Neuroscience Solutions
Orlando, Florida 32801

Florida Institute for Clinical Research
Orlando, Florida 32825

Progressive Medical Research
Port Orange, Florida 32127

Charter Research - The Villages
The Villages, Florida 32162

Nsc Research
Johns Creek, Georgia 30024

Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group
Union City, Georgia 30291

North Georgia Clinical Research
Woodstock, Georgia 30189

Solaris Clinical Research
Meridian, Idaho 83646

Endeavor Health
Skokie, Illinois 60077

Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division
Troy, Michigan 48098

Sky Integrative Medical Center
Ridgeland, Mississippi 39157

Excel Clinical Research
Las Vegas, Nevada 89109

Rochester Clinical Research
Rochester, New York 14609

Centricity Research Morehead City Specialty
Morehead City, North Carolina 28557

Accellacare of Raleigh
Raleigh, North Carolina 27609

Accellacare Research of Wilmington
Wilmington, North Carolina 28401

Lynn Health Science Institute
Oklahoma City, Oklahoma 73112

Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635

Epic Medical Research - DeSoto
DeSoto, Texas 75115

South Texas Research Institute
Edinburg, Texas 78539

Biopharma Informatic, LLC
Houston, Texas 77043

Research Physicians Network, LLC
Houston, Texas 77089

Texas Institute of Cardiology
McKinney, Texas 75071

North Hills Medical Research
North Richland Hills, Texas 76180

VIP Trials
San Antonio, Texas 78230

Northwest Houston Heart Center
Tomball, Texas 77375

Eastside Research Associates Health Research
Redmond, Washington 98052

Puerto Rico Medical Research Inc.
Ponce, Puerto Rico 00717

More Details

Status
Recruiting
Sponsor
Amgen

Study Contact

Amgen Call Center
866-572-6436
medinfo@amgen.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.