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Purpose

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

Eligible participants for this study include: - adults aged 18 years or older with - obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with - overweight (BMI of 27.0 kg/m2 to <30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.

Exclusion Criteria

Participants who are not eligible include those with diabetes mellitus, a body weight change of >5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Cohort 1 		Participants receive subcutaneous injections of PF-08653945 or placebo.
  • Drug: PF-08653945
    Subcutaneous Injection
  • Drug: Placebo
    Subcutaneous Injection
Experimental
Cohort 2 		Participants receive subcutaneous injections of PF-08653945 + PF-08653944 or placebo.
  • Drug: PF-08653945
    Subcutaneous Injection
  • Drug: PF-08653944
    Subcutaneous Injection
  • Drug: Placebo
    Subcutaneous Injection
Experimental
Cohort 3 		Participants receive subcutaneous injections of PF-08653945 + PF-08653944 , PF-08653944 , or placebo.
  • Drug: PF-08653945
    Subcutaneous Injection
  • Drug: PF-08653944
    Subcutaneous Injection
  • Drug: Placebo
    Subcutaneous Injection

Recruiting Locations

Arizona Clinical Trials-Chandler
Chandler, Arizona 85225

Clinical Research Institute of Arizona
Sun City West, Arizona 85375

Arizona Clinical Trials (ACT) - Tucson
Tucson, Arizona 85711

San Fernando Valley Health Institute
Canoga Park, California 91304

Ark Clinical Research
Fountain Valley, California 92708

Paragon Rx Clinical
Garden Grove, California 92840

Torrance Clinical Research Institute, Inc.
Lomita, California 90717

Ark Clinical Research
Long Beach, California 90815

Collaborative Neuroscience Research, LLC
Los Alamitos, California 90720

Paradigm Clinical Research-Modesto
Modesto, California 95355

Paradigm Clinical Research Centers, LLC
San Diego, California 92108

University Clinical Investigators, Incorporated
Tustin, California 92780

Diablo Clinical Research, LLC dba Flourish Research
Walnut Creek, California 94598

AGA Clinical Trials
Hialeah, Florida 33012

Westside Center for Clinical Research
Jacksonville, Florida 32205

New Horizon Research Center
Miami, Florida 33165

Charter Research
Orlando, Florida 32803

Atlanta Diabetes Associates
Atlanta, Georgia 30318

Clinical Research Atlanta
Stockbridge, Georgia 30281

Koch Family Medicine Clinical Research/Elite Research Network
Morton, Illinois 61550

Bioluminux Clinical Research Illinois
Naperville, Illinois 60540

Johnson County Clinical Trials
Lenexa, Kansas 66219

DelRicht Research
Mandeville, Louisiana 70471

DelRicht Research
Prairieville, Louisiana 70769

Patient First Clinical Trials (PFCTRIALS)
Lutherville, Maryland 21093

DelRicht Research
Springfield, Missouri 65807

Mercury Street Medical Group, PLLC
Butte, Montana 59701

Alliance Clinical Research Las Vegas (Excel Clinical Research)
Las Vegas, Nevada 89109

AB Clinical Trials
Las Vegas, Nevada 89119

Palm Research Center
Las Vegas, Nevada 89128

Bioluminux Clinical Research
Hamilton, New Jersey 08690

DelRicht Research
Charlotte, North Carolina 28210

Monroe Biomedical Research
Monroe, North Carolina 28112

Piedmont Healthcare
Statesville, North Carolina 28625

Accellacare - Wilmington
Wilmington, North Carolina 28401

Tekton Research, LLC.
Edmond, Oklahoma 73013

Preferred Primary Care Physicians
Pittsburgh, Pennsylvania 15236

Preferred Primary Care Physicians, Inc.
Uniontown, Pennsylvania 15401

Preferred Primary Care Physicians
Uniontown, Pennsylvania 15401

TMA Headlands LLC (d/b/a Trial Management Associates)
Myrtle Beach, South Carolina 29572

DelRicht Research
Hendersonville, Tennessee 37075

Cedar Health Research - Euless
Euless, Texas 76040

JCCT-JUNO NW Houston
Houston, Texas 77040

Activian Clinical Research
Kingwood, Texas 77339

3A Research
Plano, Texas 75093

DelRicht Research @ Zomnir Family Medicine
Prosper, Texas 75078

Worldwide Clinical Trials
San Antonio, Texas 78217

Tekton Research, LLC.
San Antonio, Texas 78258

Consano Clinical Research, LLC
Shavano Park, Texas 78231

DM Clinical Research
Tomball, Texas 77375

Alpine Medical Group
Salt Lake City, Utah 84102

Wasatch Clinical Research, LLC
Salt Lake City, Utah 84107

Washington Center for Weight Management and Research
Arlington, Virginia 22206

Manassas Clinical Research Center
Manassas, Virginia 20110

DelRicht Research
Vienna, Virginia 22182

More Details

Status
Recruiting
Sponsor
Pfizer

Study Contact

Pfizer CT.gov Call Center
1-800-718-1021
ClinicalTrials.gov_Inquiries@pfizer.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.