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Purpose

The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment. Aim 1. We want to sort adolescents and young adults with long lasting muscle and bone pain into two different groups. To do this, we will look at participants' childhood medical histories, past treatments, when their pain started, the sex they were assigned at birth, what their pain feels like now, tests of how their body senses pain, and immune system markers found in their blood. We think we will find at least two different types of chronic pain groups, plus one group of patients who had a higher risk for pain (because of a rheumatic disease or past surgery) but never developed long term pain. Aim 2. We want to find out if certain patterns of inflammation in the body change how nerve cells react to pain. Aim 3: We want to understand how different biological, psychological, and social factors are connected to the chronic pain groups we identified. We think we will find certain mental, behavioral, and social risks-as well as protective factors-that help explain why some people develop long-lasting pain and others do not. We expect these factors to play different roles in each pain group, including the group that does not develop chronic pain.

Conditions

Eligibility

Eligible Ages
Between 14 Years and 26 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Diagnosis of rheumatic/autoimmune disease/pain condition or surgery prior to age 18; Current age 14 to 26 years; Participant (and parent/legal guardian of participants < 18 yo) can read and write in English; At least 1 year from diagnosis of pain or rheumatic disease; For individuals with MSK surgical history, at least 1 year after initial surgical intervention; For individuals with rheumatic disease, their disease must be considered inactive

Exclusion Criteria

  • They have active disease, or Other major medical comorbidities have developed after surgery following MSK surgical intervention.

Study Design

Phase
Study Type
Observational [Patient Registry]
Observational Model
Cohort
Time Perspective
Cross-Sectional

Arm Groups

ArmDescriptionAssigned Intervention
Primary musculoskeletal pain disorders localized or widespread MSK pain
  • Other: Not applicable- observational study
    This is an observational study. No intervention is present.
Inflammatory/autoimmune rheumatic diseases juvenile idiopathic arthritis (JIA) and childhood-onset systemic lupus erythematosus (cSLE)
  • Other: Not applicable- observational study
    This is an observational study. No intervention is present.
Major MSK surgeries scoliosis and pectus excavatum repair
  • Other: Not applicable- observational study
    This is an observational study. No intervention is present.

Recruiting Locations

Cincinnati Children's Hospital
Cincinnati, Ohio 45211
Contact:
Megan Kirschman
5136361846
bridgestudy@cchmc.org

More Details

Status
Recruiting
Sponsor
Children's Hospital Medical Center, Cincinnati

Study Contact

Megan Kirschman
5136361846
bridgestudy@cchmc.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.