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Purpose

Early feasibility study to establish quantitative physiological markers correlated with noninvasive stimulation.

Condition

Eligibility

Eligible Ages
Between 18 Years and 65 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Able to provide written informed consent in English. - Willing and able to complete study procedures (e.g., ~1-hour sessions with non-invasive recordings, ~3-hour visit).

Exclusion Criteria

  • History of neurological disorders (e.g., epilepsy, migraines) or psychiatric conditions requiring medication. - Active implanted medical devices (e.g., pacemakers, cochlear implants) or metal in the neck/forearm that could interfere with stimulation or recordings. - Skin conditions or open wounds at stimulation sites (cervical neck, forearm). - Women who are pregnant or breastfeeding. - Current use of medications affecting autonomic or cortical function (e.g., beta-blockers, sedatives). - Inability to sit still for recordings or understand instructions (e.g., due to severe vision/hearing impairment).

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Intervention Model Description
This is a single-site exploratory study.
Primary Purpose
Basic Science
Masking
Single (Participant)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Acute electrical stimulation session versus no stimulation (sham).
  • Device: External electrical stimulation
    Electrical stimulation
Experimental
Acute ultrasound stimulation session versus no stimulation (sham).
  • Device: Ultrasound stimulation
    USS

Recruiting Locations

M Health Clinical Research Unit
Minneapolis, Minnesota 55455
Contact:
Principal investigator
612-624-1326
tntlab-studies@umn.edu

M Health Clinics and Surgery Center and satellite Neurology Clinic locations
Minneapolis, Minnesota 55455
Contact:
Principal investigator
612-624-1326
tntlab-studies@umn.edu

Translational Neurotechnology (TNT) Lab
Minneapolis, Minnesota 55455
Contact:
Principal Investigator, PhD
612-624-1326
tntlab-studies@umn.edu

More Details

Status
Recruiting
Sponsor
University of Minnesota

Study Contact

Rosana Esteller, Principal Investigator, PhD
612-624-1326
tntlab-studies@umn.edu

Detailed Description

This pilot early feasibility study in healthy participants is intended to establish quantitative physiological markers of cortical and autonomic modulation evoked by noninvasive electrical and/or ultrasound stimulation of the nervous system.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.