Dysautonomia International

Malignant Polyp Registry

Purpose

The purpose of this study is to learn more about malignant colorectal polyps and the risk of the cancer remaining, coming back, or spreading after the polyp is removed. The researchers also want to understand how patients and doctors make decisions about treatment after a malignant polyp is removed. Additionally, the researcher will collect information medical records, including results from tests, imaging scans, lab work, and pathology reports. The researchers may also collect images from your colonoscopy and copies of pathology slides the polyp. The researchers will also follow the patient's health over time through regular doctor visits. If the patient does not have a scheduled visit, a member of the study team will contact the patient by phone at 1 year, 3 years, and 5 years after the patient joins the study to ask about their health.

Condition

Malignant Polyp

Eligibility

Eligible Ages: Over 18 Years
Eligible Sex: All
Accepts Healthy Volunteers: No

Criteria

Criteria:

- Documentation of Disease

- Patients must have one malignant polyp, pathologically confirmed within 90 days of
enrollment. Patients with multiple malignant polyps are not eligible.

- Definition of Disease Colorectal carcinoma (CRC) develops within serrated or
adenomatous polyps. Early CRC represents invasion into the submucosa and frequently
presents within the precursor polyp which is termed a 'malignant polyp'(23).

The term malignant polyp specifically refers to a colorectal lesion with cancer invading
the submucosa but not extending into the muscularis propria. These lesions are classified
as pT1 in the TNM classification system (24)

Prior Treatment Endoscopic resection of the polypoid lesion-malignant polyp with simple
snare polypectomy, conventional endoscopic mucosal resection (EMR), or endoscopic
submucosal dissection (ESD) (25).

- Age ≥ 18