1. Male or female, aged ≥ 50 years at Screening Visit 1. 2. Must agree to use an acceptable form of contraception. 3. Have diagnosis of bilateral CNV secondary to nAMD. 4. Meet ETDRS BCVA letter score criteria: - For Ixo-vec-experienced participants: Contralateral eye has an ETDRS BCVA letter score within a protocol-defined range appropriate for nAMD clinical trials. - For Ixo-vec-naïve participants: Both the initial eye and contralateral eye have ETDRS BCVA letter score within a protocol-defined range appropriate for nAMD clinical trials 5. Have prior treatment history consistent with protocol-defined requirements, including prior anti-VEGF therapy and, where applicable, prior Ixo-vec exposure. 6. Demonstrate a meaningful anatomic response to anti-VEGF in the contralateral eye (all participants) and in the initial eye (Ixo-vec-naïve participants only). Meaningful anatomic response to prior anti-VEGF therapy as defined in the protocol. 7. Able to comply with study procedures according to the Investigator's judgment. Other protocol-defined INCLUSION CRITERIA apply.

A/ General Exclusion Criteria 1. Have history of a medical condition (systemic disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding) giving reasonable suspicion of a condition that contraindicates the use of Ixo-vec, compromises the participant's ability to comply with the planned study assessments, or that might affect the interpretation of the results of the study or render the participant at high risk for treatment complications in the opinion of the Investigator. History of severe coronavirus disease of 2019 (COVID-19) infection may meet this exclusion criterion if, in the opinion of the Investigator, it is likely to lead to any of the complications listed above. 2. Received prior gene therapy (other than Ixo-vec, where applicable) 3. Currently receiving steroids at Screening Visit 1 in the previously treated eye (Ixo-vec-experienced participants) or in either eye (Ixo-vec-naïve participants). 4. Received any non-gene IMP or medical device in the contralateral eye (and/or initial eye for Ixo-vec-naïve participants) within 3 months of Screening Visit 1 5. Have history of allergy, hypersensitivity, or contraindications to the use of any product or its excipients administered as part of this study. 6. Have evidence of poorly controlled diabetes or glycated hemoglobin (HbA1c) ≥ 8.0% 7. Have history or evidence of cardiovascular diseases and ongoing bleeding disorders as defined by the protocol. 8. Use of systemic immunosuppressive therapy within a protocol-defined period. 9. Received systemic anti-VEGF therapy within a protocol-defined period. 10. Have history of malignancy within the 5 years prior to Screening Visit 1, except for adequately treated malignancies as defined by the protocol. B/Ocular Exclusion Criteria 11. Have any active ocular or periocular infection in the contralateral eye in the contralateral eye (all participants) or in the initial eye (Ixo-vec-naïve participants only). 12. Have any history or evidence of a concurrent intraocular condition in the contralateral eye (all participants) or in the initial eye (Ixo-vec-naïve participants only), including retinal diseases other than nAMD, that, in the judgment of the Investigator, could reduce the potential for visual improvement, confound assessment of the macula or require medical or surgical intervention during the study. 13. Have prior ocular surgery or treatment that may confound assessment or increase risk. 14. Have any history or evidence of retinal detachment (with or without repair) or retinal pigment epithelium rip/tear in the contralateral eye (all participants) or in the initial eye (Ixo-vec-naïve participants only), as determined by the Investigator. 15. Have uncontrolled ocular hypertension or glaucoma as defined by the protocol. 16. Have any history of inflammatory anterior chamber cell or vitreous cell ≥ 2+ in the initial eye, that, in the opinion of the Investigator and Sponsor, predisposes the contralateral eye to a heightened risk of intraocular inflammation. Enrollment of a participant with prior anterior chamber cell or vitreous cell ≥2+ in the initial eye requires discussion with the medical monitor. Other protocol-defined EXCLUSION CRITERIA apply.