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Purpose

The aim of this randomized interventional trial is to understand the effects of peanut consumption on patients with metabolic associated fatty liver. The main goal is to investigate if patients who consume peanuts have improved liver marker tests as well as metabolic profile. We will also investigate how peanuts alter the gut microbes and liver fat content in patients with metabolic associated fatty liver. - Participants will be randomized into intervention (peanut consumption for 12 weeks) and control (regular diet) arm. - Stool sample and blood (for biomarkers) collection across both arms at baseline and post-intervention - Daily log to be completed for tracking peanut consumption - 2-day Dietary recall at baseline, during Week 6 and Week 12 - Poat intervention Fibro scans for participants with baseline scans available

Conditions

Eligibility

Eligible Ages
Between 30 Years and 70 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • 30-70 years - do not consume peanut/peanut butter/treenut/seeds > /week - at least one encounter-related (stage F0/F1) MASLD diagnosis (K76.0) - Able to understand, speak, and read English - Mentally competent to consent

Exclusion Criteria

  • Food allergy to peanuts or peanut-containing products - With alcohol use disorder (AUDIT screening) - Leukemia - Lymphoma - Other types of cancer - Heart or cardiovascular diseases (such as heart attack, stroke, heart failure) - Kidney diseases (such as chronic kidney disease, kidney transplant, renal insufficiency such as renal failure requiring dialysis)

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Supportive Care
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Peanut 		MASLD patients will consume 50 gm of peanut daily for 12 weeks
  • Other: Peanut consumption
    MASLD patients will consume 50 gm of peanut daily for 12 weeks
No Intervention
Control 		Regular diet

Recruiting Locations

Henry Ford Health System
Detroit, Michigan 48202
Contact:
Menghua Tao, Ph.D.
3138768471
mtao1@hfhs.org

More Details

Status
Recruiting
Sponsor
Henry Ford Health System

Study Contact

Menghua Tao, PhD
313-590-9408
mtao1@hfhs.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.