Eligibility

Eligible Ages

Between 21 Years and 105 Years

Eligible Sex

All

Accepts Healthy Volunteers

Yes

Criteria

Inclusion

Participants must meet all the following criteria:

- Adults, at least 21 years of age at the time of electronic consent, inclusive of all
ethnicities, races, and gender identities

- Assigned sex at birth will determine sex-specific recruitment and PROs (male vs
female) employed, when needed

- Resides in the United States

- Has the opportunity for at least 30% improvement in their primary health outcome

- Expresses a willingness to take a study product and not know the product identity
(active or placebo) until the end of the study

Exclusion

Individuals who report any of the following during screening may be excluded from
participation:

- Report being pregnant, trying to become pregnant, or breastfeeding

- Unable to provide a valid US shipping address and mobile phone number

- Reports current enrollment in another clinical trial and/or use of investigational
drugs

- Reports being a heavy drinker (defined as drinking 3 or more alcoholic beverages per
day)

- Unable to read and understand English at a 7th grade level

- Reports a current and/or recent (up to 3 months ago) major illness and/or surgery
that poses a known, significant safety risk.

- Reports a diagnosis of cardiac dysfunction, liver or kidney disease that presents a
known contraindication and/or a significant safety risk with any of the study
product ingredients.

- NYHA Class III or IV congestive heart failure, atrial fibrillation,
uncontrolled arrhythmias, cirrhosis, end-stage liver disease, stage 3b or 4
chronic kidney disease, or kidney failure

- Reports taking medications that have a well-established moderate or severe
interaction, posing a substantial safety risk with any of the study product
ingredients.

- Anticoagulants, antihypertensives, anxiolytics, antidepressants, chemotherapy,
immunotherapy, sedative hypnotics, seizure medications, medications that warn
against grapefruit consumption, corticosteroids at doses greater than 5 mg per
day, diabetic medications, oral anti-infectives (antibiotics, antifungals,
antivirals) to treat an acute infection, antipsychotics, MAOIs, or thyroid
products

- Reports current use of the primary ingredient(s) and/or similar product(s) to the
active study product(s) that may limit the effects of the study products and/or pose
a safety risk

- Reports illicit drug use

- Reports a cancer diagnosis within the last 2 years

- Reports current use of weight loss or appetite modifying medications or supplements
(including GLP-1 receptor agonists)

- Reports current use of prescription stimulant, sedative, sleep, or other central
nervous system-active medications

- Reports current use of prebiotics/probiotics, multivitamin supplements, gut health
supplements, synbiotics, greens powders

- Lack of reliable daily access to the internet

- Participants residing in the states of New York, New Jersey, or Rhode Island are
eligible to enroll in the main study and will complete all primary study activities.
However, these participants are not eligible to participate in the biomarker
sub-study. This restriction is due to state regulatory requirements governing
direct-to-consumer at-home laboratory specimen collection and processing that cannot
be accommodated within the fully decentralized design of the sub-study. No
alternative collection pathway is available under the current protocol. To ensure
compliance, state-of-residence logic is built into the enrollment platform.
Participants who indicate a residential address in New York, New Jersey, or Rhode
Island will not be presented with the biomarker sub-study consent or any associated
study materials. This automated screening ensures that ineligible participants are
not inadvertently enrolled in the sub-study. These participants will otherwise
proceed through full main study enrollment and participation without interruption.