Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
Purpose
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
Conditions
- Women
- Aging
- Menopause
Eligibility
- Eligible Ages
- Between 18 Years and 70 Years
- Eligible Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Healthy women, - Assigned female at birth, - 18-70 years of age, - Body mass index <18 or ≥30 kg/m2,
Exclusion Criteria
- Assigned male at birth, - Pregnancy, - Breastfeeding, - History of hormone replacement therapy, chemical menopause, or oophor-ectomy - Polycystic ovarian syndrome or Primary ovarian insufficiency, - Current smoking/Nicotine use, - Blood pressure ≥140/90 mmHg, - Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy, - Nerve/neurologic disease, - Cardiovascular, hepatic, renal, respiratory disease, - Hypersensitivity to nitroglycerin, - Diabetes, - Communication barriers,
Study Design
- Phase
- Early Phase 1
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Cold pressor test |
Participants will be exposed to the cold pressor test (ice water on the foot). |
|
|
Experimental Flow Mediated Dilation |
Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm. |
|
Recruiting Locations
University of Missouri
Columbia, Missouri 65211
Columbia, Missouri 65211
More Details
- Status
- Recruiting
- Sponsor
- University of Missouri-Columbia