Effect of Anti-inflammatory Diet in Systemic Lupus Erythematous
Purpose
To study the effect of anti-inflammatory diet on clinical and biological outcomes in lupus
Condition
- Systemic Lupus Erthematosus (SLE)
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- patients who meet the 2019 EULAR/ACR Classification Criteria for SLE - patients who are on Cellcept or Myfortic for at least 3 months prior to screening - patients with a score of ≥55 on the Patient Reported Outcomes Measurement Information System (PROMIS) Pain interference scale.
Exclusion Criteria
- pregnant or lactating patients, - patients with food allergy - patients on antibiotics within 4 weeks of the screening - patients that change the SLE therapy during the length of the study (12 weeks).
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Intervention Model Description
- anti-inflammatory diet for 6 weeks
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental anti-inflammatory diet |
anti-inflammatory diet |
|
Recruiting Locations
Altman Clinical Translational Research Insitute (UC San Diego)
La Jolla, California 92097
La Jolla, California 92097
More Details
- Status
- Recruiting
- Sponsor
- University of California, San Diego
Detailed Description
The investigators aim to evaluate how inflammation changes in individuals with lupus and to identify molecules and gut bacteria that may help predict disease flares. Blood and stool samples will be analyzed in the laboratory and compared with samples collected from the same participants following dietary changes. This is an exploratory study designed to generate preliminary data on the short-term effects of dietary changes and treatment on blood biomarkers and the gut microbiome. The findings may provide insights into the mechanisms underlying lupus and could ultimately contribute to the development of new therapeutic approaches.