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Purpose

This study is being done to determine how easy it is to use standard of care (SOC) surgical resections or biopsy for SmartMatch analysis to determine treatment options in advanced gynecological malignancies.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age ≥ 18 years - Histologically confirmed rare gynecologic malignancy, including but not limited to those listed - Metastatic or unresectable disease, OR disease for which additional systemic therapy is indicated - Fresh tumor tissue available from a SOC surgical procedure or biopsy that in the judgment of the treating team will yield adequate viable tumor for SmartMatch analysis - Eastern Cooperative Oncology Group (ECOG) performance status 0-2 - Adequate organ function to receive systemic therapy as determined by the treating oncologist (protocol does not specify thresholds because therapy is not mandated) - Ability to understand and willingness to sign informed consent - Willingness to allow data abstraction from the electronic health record for study endpoints

Exclusion Criteria

  • Lack of tumor tissue suitable for SmartMatch analysis - Purely borderline tumors or benign ovarian/uterine neoplasms - Any condition that, in the opinion of the treating oncologist or PI, would interfere with receiving systemic therapy - Inability to provide informed consent or comply with study procedures

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Observational - SmartMatch laboratory analysis Patients undergo tissue sample collection obtained from standard of care surgical resection or biopsy for SmartMatch laboratory analysis and have their medical records reviewed on study.

Recruiting Locations

Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington 98109
Contact:
Kalyan Banda, MD
206-606-2222
bkalyan@uw.edu

More Details

Status
Recruiting
Sponsor
Fred Hutchinson Cancer Center

Study Contact

Kalyan Banda, MD
206-606-2222
bkalyan@uw.edu

Detailed Description

OUTLINE: This is an observational study. Patients undergo tissue sample collection obtained from standard of care surgical resection or biopsy for SmartMatch laboratory analysis and have their medical records reviewed on study.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.