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Purpose

The purpose of this research is to evaluate the feasibility and effectiveness of Digital Neurotherapy (DNT) or Capacity Coaching (CC) for managing symptoms of depression and self reported pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to education alone.

Condition

Eligibility

Eligible Ages
Between 18 Years and 70 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria - Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR >10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months) - Clinical or self-diagnosis of depression - English-language fluency

Exclusion Criteria

  • Suicidal ideation/unstable mental illness of any kind - Lack of access/ability to use internet-based programs - eGFR <10 ml/min/1.73m2 - Anticipated dialysis or transplant within 6 months - Prior chronic dialysis - Prior organ (liver or kidney) transplant - Lack of English language fluency - Significant cognitive impairment (Mini Mental Status Exam (MMSE))

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Mayo Clinic-Approved Education 		The control group will receive standard of care, Mayo Clinic approved education for a duration of 60 minutes, every 2 weeks for 6 sessions (12 weeks)
  • Behavioral: Mayo Clinic-Approved Education
    Education attention control will be administered by board certified health and wellness coaches via virtual coaching sessions.
Experimental
Digital Neuropathy 		The Digital Neuropathy group will utilize the web-based system (REJUVENATE) for a duration of 20 minutes, 4 times per week (12 weeks)
  • Behavioral: Digital Neuropathy
    The web-based system (REJUVENATE) consists of a set of cognitive exercises continuously and automatically adjusted in difficulty based on each user's performance to maintain the balance of challenge and success optimal to promote neuroplastic enhancement of target neural systems.
    Other names:
    • REJUVENATE
Experimental
Capacity Coaching 		The Capacity Coaching group will participate in calls with a board certified health and wellness coach for a duration of 60 minutes, every 2 weeks, for 6 sessions (12 weeks)
  • Behavioral: Capacity Coaching
    Board certified health and wellness coaches will create a plan with subjects to use capacity, defined as patients' abilities and resources, to do self-management work.

Recruiting Locations

Mayo Clinic
Rochester, Minnesota 55905
Contact:
Ryan Helland, CCRP
507-422-3998

More Details

Status
Recruiting
Sponsor
Mayo Clinic

Study Contact

Ryan Helland, CCRP
507-422-3998
RSTTEMPORESGROUP@mayo.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.