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Purpose

The purpose of the study is to explore the best ways of giving radiation therapy to balance cancer control and treatment side effects.

Conditions

Eligibility

Eligible Ages
All ages
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Non-metastatic prostate cancer. - Classified as unfavorable intermediate-, high-, or very high-risk prostate cancer according to NCCN risk stratification guidelines. (Note: cT3a or T3b by MRI or PSMA PET allowed) - Considered by the treating radiation oncologist as a suitable candidate for both HDR brachytherapy boost and SBRT

Exclusion Criteria

  • None

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Arm A: HDR Brachytherapy Boost + SBRT 		Standard of Care Brachytherapy/Radiation and SBRT
  • Radiation: Standard of Care HDR Brachytherapy
    HDR Brachytherapy
  • Radiation: SBRT
    SBRT alone
Experimental
Arm B: SBRT Alone 		SBRT alone
  • Radiation: SBRT
    SBRT alone

Recruiting Locations

Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey 07920
Contact:
Daniel Gorovets, MD
212-639-3983

Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)
Middletown, New Jersey 07748
Contact:
Daniel Gorovets, MD
212-639-3983

Memorial Sloan Kettering at Bergen (Limited Protocol Activities)
Montvale, New Jersey 07645
Contact:
Daniel Gorovets, MD
212-639-3983

Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)
Commack, New York 11725
Contact:
Daniel Gorovets, MD
212-639-3983

Memorial Sloan Kettering at Westchester (Limited Protocol Activities)
Harrison, New York 10604
Contact:
Daniel Gorovets, MD
212-639-3983

Memorial Sloan Kettering Cancer Center (All Protocol Activites)
New York, New York 10065
Contact:
Daniel Gorovets, MD
212-639-3983

Memorial Sloan Kettering at Nassau (Limited Protocol Activities)
Uniondale, New York 11553
Contact:
Daniel Gorovets, MD
212-639-3983

More Details

Status
Recruiting
Sponsor
Memorial Sloan Kettering Cancer Center

Study Contact

Daniel Gorovets, MD
212-639-3983
gorovetd@mskcc.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.