Eligibility

Eligible Ages

Between 18 Years and 45 Years

Eligible Sex

All

Accepts Healthy Volunteers

Yes

Criteria

Cocaine use disorders (CUD)

1. Males or females between 18 and 45 years old.

2. fulfill DSM-5 criteria for moderate or severe (4+ criteria) cocaine use disorder.

3. No lifetime DSM-5 schizophrenia, schizoaffective disorder, bipolar disorder, and
developmental disorders.

4. No comorbid DSM-5 major depressive or severe anxiety disorders (including
cocaine-induced mood and anxiety disorders) in the past 12 months.

5. No comorbid DSM-5 alcohol, opioids, sedative-hypnotics, hallucinogens, and inhalant
use disorders in the past 12 months. Subjects with a moderate to severe DSM-5
cannabis use disorder will also be excluded.

6. Not currently on psychotropic or medical medications that can influence binding to
MC-I (e.g., metformin) or CGM (e.g., insulin, GLP-1 agonists), or increase the risks
associated with an arterial line (e.g., warfarin, clopidogrel, aspirin, naproxen,
ibuprofen, etc.).

7. No comorbid medical disorders that can influence the PET outcome measures (for
example, MC-I binding is altered in Parkinson' disease, mild or major neurocognitive
disorders, mitochondrial disorders, immune disorders; and CGM is altered in
diabetes, severe hyperlipidemia, hypertension, obesity), or are a contraindication
for blood sampling (anemia), or placement of an arterial line (history of deep vein
thrombosis, pulmonary embolism, thrombocytopenia or thrombocytosis).

8. Not currently pregnant or breast-feeding.

9. Not currently employed as radiation worker; or has not participated in a
radiation-related research protocol within the previous year such that the total
cumulative annual radiation dose (i.e., from participation in previous radioactive
drug studies and this study) would exceed the radiation dose limits specified in the
FDA regulations (i.e., 21 CFR 361.1) that govern the research use of radiotracers.

10. No medical or psychiatric contraindications to undergo an MRI scan (such as
ferromagnetic tattoos/piercings, implants, medical equipment, history of gunshot,
and claustrophobia).

Healthy controls (HC)

1. Males or females between 18 and 45 years old.

2. No DSM-5 psychiatric or substance use disorder other than tobacco use disorder

3. 6 to 10 above.