Reducing Blood Pressure in Mid-life Adult Binge Drinkers
Purpose
This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers
Conditions
- Alcohol Drinking
- Binge Drinking
- Blood Pressure
- Alcohol Abstinence
- Aging
- Lifestyle Factors
- Vasodilation
- Behavioral Problem
Eligibility
- Eligible Ages
- Between 50 Years and 64 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink - Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr). - Subjects who can speak and understand English.
Exclusion Criteria
- a history of diabetes, cardiovascular disease, liver, or renal disease - current or history of smoking and illicit drug use - blood pressure ≥160/100 mm Hg - other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol>230 mg/dl and/or LDL cholesterol>160 mg/dl) - active infection (in the past 2 months) - a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid) - unstable body weight (>5% change during the past 6 months) - regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week) - current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Prevention
- Masking
- Double (Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Exercise Group |
Binge drinkers who have been assigned to exercise group will receive baseline assessment, 8-week exercise training plus alcohol abstinence intervention, and post-intervention assessment. |
|
|
Active Comparator Non-exercise Group |
Binge drinkers who have been assigned to non-exercise group will receive baseline assessment, 8-week alcohol abstinence intervention, and post-intervention assessment. |
|
|
No Intervention Alcohol abstainer/moderate drinker group |
Alcohol abstainer/moderate drinker will complete baseline assessment only and will not receive any intervention. |
|
Recruiting Locations
Arlington 4671240, Texas 4736286 76010
More Details
- Status
- Recruiting
- Sponsor
- The University of Texas at Arlington
Detailed Description
During phase 1, we will measure blood pressure, microvascular function, and sympathetic nerve activity (baseline assessment) in mid-life adult binge drinkers, alcohol abstainers, and moderate drinkers. Only mid-life adult binge drinkers will enter Phase 2 and be randomized to the exercise training group and non-exercise control group. After 8 weeks of intervention, we will re-measure blood pressure, microvascular function, and sympathetic nerve activity (post-intervention assessment) in mid-life adult binge drinkers.