Cerebrovascular Dysregulation in Chronic Kidney Disease
Purpose
The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).
Condition
- Chronic Kidney Diseases
Eligibility
- Eligible Ages
- Between 30 Years and 75 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
• Individuals with chronic kidney disease stages III-IV.
Exclusion Criteria
- Heart failure - Chronic obstructive pulmonary disease - Uncontrolled hypertension or hypotension - Pregnancy or plans to become pregnant - Inability to exercise on a stationary bicycle - Current participation in exercise more than 20 minutes twice per week
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Intervention Model Description
- Participants will be assigned to one of two conditions:1) aerobic exercise training on a stationary bicycle, or 2) stretching and balance training.
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Exercise Training |
Participants will exercise 3 times a week on a stationary bicycle. Exercise intensity will begin at low levels (50% of maximal heart rate reserve) and increase as tolerated to a maximum of 80% of maximal heart rate reserve. Exercise time will progress from an initial 20 minutes per session to a maximum of 45 minutes per session. |
|
|
Placebo Comparator Stretching |
Participants will undergo progressive whole body stretching and balance exercises. This type of low intensity exercise is designed not to increase heart rate but rather to improve joint mobility and the ability to perform activities of daily living. This will serve as the control group to the exercise group. The control group will come in for stretching sessions 3 times per week for 20-45 minutes. |
|
Recruiting Locations
University of North Texas
Denton, Texas 76203
Denton, Texas 76203
More Details
- Status
- Recruiting
- Sponsor
- University of North Texas, Denton, TX
Detailed Description
Prior research has shown that CKD patients have an increased risk of stroke and that impairments in brain blood flow regulation predict stroke in other chronic disease states. This study will test whether exercise training can improve brain blood flow regulation via improved dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in CKD. Participants will undergo exercise training on a stationary bicycle, or stretching exercises, 3 times per week for 12 weeks.