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Purpose

The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.

Condition

Eligibility

Eligible Ages
Over 40 Years
Eligible Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Aortic stenosis (valve area <1.5cm2)

Exclusion Criteria

  • Bicuspid aortic valve - History of radiation to chest - Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis - Active cancer

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Males with aortic stenosis Males with mild or greater aortic stenosis (aortic valve area <1.5 cm2) due to calcific non-congenital aortic stenosis.
  • Diagnostic Test: Blood analysis for loss-of-Y chromosome
    Analysis for the percentage of circulating leukocytes with loss-of-y chromosome
Control males without aortic stenosis Males without any diagnosis for aortic stenosis (matched for aortic stenosis group).
  • Diagnostic Test: Blood analysis for loss-of-Y chromosome
    Analysis for the percentage of circulating leukocytes with loss-of-y chromosome

Recruiting Locations

University of Virginia
Charlottesville, Virginia 22903
Contact:
Jonathan Lindner
503-260-0672
jlindner@virginia.edu

More Details

Status
Recruiting
Sponsor
University of Virginia

Study Contact

Jonathan R Lindner, MD
434 2979442
jlindner@virginia.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.